In this case, the true-breeding plants had homozygous YY genotypes, whereas the segregating plants corresponded to the heterozygous Yy genotype. When these plants self-fertilized, the outcome was just like the F 1 self-fertilizing cross. Beyond predicting the offspring of a cross between known homozygous or heterozygous parents, Mendel also developed a way to determine whether an organism that expressed a dominant trait was a heterozygote or a homozygote. Called the test cross , this technique is still used by plant and animal breeders.
In a test cross, the dominant-expressing organism is crossed with an organism that is homozygous recessive for the same characteristic. In pea plants, round peas R are dominant to wrinkled peas r. You do a test cross between a pea plant with wrinkled peas genotype rr and a plant of unknown genotype that has round peas. You end up with three plants, all which have round peas.
From this data, can you tell if the round pea parent plant is homozygous dominant or heterozygous? If the round pea parent plant is heterozygous, what is the probability that a random sample of 3 progeny peas will all be round? Many human diseases are genetically inherited.
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A healthy person in a family in which some members suffer from a recessive genetic disorder may want to know if he or she has the disease-causing gene and what risk exists of passing the disorder on to his or her offspring. Of course, doing a test cross in humans is unethical and impractical. Affected individuals may have darkened skin and brown urine, and may suffer joint damage and other complications. In this pedigree, individuals with the disorder are indicated in blue and have the genotype aa.
Unaffected individuals are indicated in yellow and have the genotype AA or Aa.
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For example, if neither parent has the disorder but their child does, they must be heterozygous. Two individuals on the pedigree have an unaffected phenotype but unknown genotype. In the sections to follow, we consider some of the extensions of Mendelism. However, the heterozygote phenotype occasionally does appear to be intermediate between the two parents. Note that different genotypic abbreviations are used for Mendelian extensions to distinguish these patterns from simple dominance and recessiveness. This pattern of inheritance is described as incomplete dominance , denoting the expression of two contrasting alleles such that the individual displays an intermediate phenotype.
The allele for red flowers is incompletely dominant over the allele for white flowers. However, the results of a heterozygote self-cross can still be predicted, just as with Mendelian dominant and recessive crosses. A variation on incomplete dominance is codominance , in which both alleles for the same characteristic are simultaneously expressed in the heterozygote. An example of codominance is the MN blood groups of humans. The M and N alleles are expressed in the form of an M or N antigen present on the surface of red blood cells.
In a self-cross between heterozygotes expressing a codominant trait, the three possible offspring genotypes are phenotypically distinct. However, the genotypic ratio characteristic of a Mendelian monohybrid cross still applies. Mendel implied that only two alleles, one dominant and one recessive, could exist for a given gene. We now know that this is an oversimplification. Although individual humans and all diploid organisms can only have two alleles for a given gene, multiple alleles may exist at the population level such that many combinations of two alleles are observed.
All other phenotypes or genotypes are considered variants of this standard, meaning that they deviate from the wild type. The variant may be recessive or dominant to the wild-type allele. Here, four alleles exist for the c gene. The chinchilla phenotype, c ch c ch , is expressed as black-tipped white fur. The Himalayan phenotype, c h c h , has black fur on the extremities and white fur elsewhere. In cases of multiple alleles, dominance hierarchies can exist.
In this case, the wild-type allele is dominant over all the others, chinchilla is incompletely dominant over Himalayan and albino, and Himalayan is dominant over albino. This hierarchy, or allelic series, was revealed by observing the phenotypes of each possible heterozygote offspring. For the allelic series in rabbits, the wild-type allele may supply a given dosage of fur pigment, whereas the mutants supply a lesser dosage or none at all.
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Alternatively, one mutant allele can be dominant over all other phenotypes, including the wild type. This may occur when the mutant allele somehow interferes with the genetic message so that even a heterozygote with one wild-type allele copy expresses the mutant phenotype. One way in which the mutant allele can interfere is by enhancing the function of the wild-type gene product or changing its distribution in the body. In this case, the mutant allele expands the distribution of the gene product, and as a result, the Antennapedia heterozygote develops legs on its head where its antennae should be.
Plasmodium falciparum and P. When promptly and correctly treated, P.
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However, in some parts of the world, the parasite has evolved resistance to commonly used malaria treatments, so the most effective malarial treatments can vary by geographic region. Varying degrees of sulfadoxine resistance are associated with each of these alleles. Being haploid, P. In Southeast Asia, different sulfadoxine-resistant alleles of the dhps gene are localized to different geographic regions. This is a common evolutionary phenomenon that occurs because drug-resistant mutants arise in a population and interbreed with other P.
Sulfadoxine-resistant parasites cause considerable human hardship in regions where this drug is widely used as an over-the-counter malaria remedy. As is common with pathogens that multiply to large numbers within an infection cycle, P. For this reason, scientists must constantly work to develop new drugs or drug combinations to combat the worldwide malaria burden. In humans, as well as in many other animals and some plants, the sex of the individual is determined by sex chromosomes.
The sex chromosomes are one pair of non-homologous chromosomes.
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Until now, we have only considered inheritance patterns among non-sex chromosomes, or autosomes. In addition to 22 homologous pairs of autosomes, human females have a homologous pair of X chromosomes, whereas human males have an XY chromosome pair. Although the Y chromosome contains a small region of similarity to the X chromosome so that they can pair during meiosis, the Y chromosome is much shorter and contains many fewer genes. When a gene being examined is present on the X chromosome, but not on the Y chromosome, it is said to be X-linked. Eye color in Drosophila was one of the first X-linked traits to be identified.
Thomas Hunt Morgan mapped this trait to the X chromosome in Because of the location of the eye-color gene, reciprocal crosses do not produce the same offspring ratios. Males are said to be hemizygous , because they have only one allele for any X-linked characteristic.
Hemizygosity makes the descriptions of dominance and recessiveness irrelevant for XY males. Clockwise from top left are brown, cinnabar, sepia, vermilion, white, and red.
Red eye color is wild-type and is dominant to white eye color. In an X-linked cross, the genotypes of F 1 and F 2 offspring depend on whether the recessive trait was expressed by the male or the female in the P 1 generation. Now, consider a cross between a homozygous white-eyed female and a male with red eyes.
What ratio of offspring would result from a cross between a white-eyed male and a female that is heterozygous for red eye color? Discoveries in fruit fly genetics can be applied to human genetics. When a female parent is homozygous for a recessive X-linked trait, she will pass the trait on to percent of her offspring. Her male offspring are, therefore, destined to express the trait, as they will inherit their father's Y chromosome.
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In humans, the alleles for certain conditions some forms of color blindness, hemophilia, and muscular dystrophy are X-linked. Females who are heterozygous for these diseases are said to be carriers and may not exhibit any phenotypic effects. These females will pass the disease to half of their sons and will pass carrier status to half of their daughters; therefore, recessive X-linked traits appear more frequently in males than females. In some groups of organisms with sex chromosomes, the gender with the non-homologous sex chromosomes is the female rather than the male.
This is the case for all birds. In this case, sex-linked traits will be more likely to appear in the female, in which they are hemizygous. Because human males need to inherit only one recessive mutant X allele to be affected, X-linked disorders are disproportionately observed in males. Females must inherit recessive X-linked alleles from both of their parents in order to express the trait. When they inherit one recessive X-linked mutant allele and one dominant X-linked wild-type allele, they are carriers of the trait and are typically unaffected.
Carrier females can manifest mild forms of the trait due to the inactivation of the dominant allele located on one of the X chromosomes. Although some Y-linked recessive disorders exist, typically they are associated with infertility in males and are therefore not transmitted to subsequent generations.
A daughter will not be affected, but she will have a 50 percent chance of being a carrier like her mother. Watch this video to learn more about sex-linked traits. Occasionally, a nonfunctional allele for an essential gene can arise by mutation and be transmitted in a population as long as individuals with this allele also have a wild-type, functional copy.
The wild-type allele functions at a capacity sufficient to sustain life and is therefore considered to be dominant over the nonfunctional allele. In one quarter of their offspring, we would expect to observe individuals that are homozygous recessive for the nonfunctional allele. Because the gene is essential, these individuals might fail to develop past fertilization, die in utero, or die later in life, depending on what life stage requires this gene. An inheritance pattern in which an allele is only lethal in the homozygous form and in which the heterozygote may be normal or have some altered non-lethal phenotype is referred to as recessive lethal.
For crosses between heterozygous individuals with a recessive lethal allele that causes death before birth when homozygous, only wild-type homozygotes and heterozygotes would be observed. He allowed the F 1 plants to self-fertilize and found that plants in the F 2 generation had violet flowers and had white flowers. This was a ratio of 3.
When Mendel transferred pollen from a plant with violet flowers to the stigma of a plant with white flowers and vice versa, he obtained approximately the same ratio irrespective of which parent—male or female—contributed which trait. This is called a reciprocal cross —a paired cross in which the respective traits of the male and female in one cross become the respective traits of the female and male in the other cross. For the other six characteristics that Mendel examined, the F 1 and F 2 generations behaved in the same way that they behaved for flower color.
One of the two traits would disappear completely from the F 1 generation, only to reappear in the F 2 generation at a ratio of roughly Figure 8. Upon compiling his results for many thousands of plants, Mendel concluded that the characteristics could be divided into expressed and latent traits. He called these dominant and recessive traits , respectively.